El glutatión
en tres etapas
de la mujer

Antes de empezar:
el cáncer de mama se gana a tiempo

Un cerebro que sigue en obra
hasta pasados los 20

Cuando el ánimo cae,
el glutatión también aparece bajo

Piel, deporte y sueño:
tres gastos diarios de glutatión

Hasta un embarazo sano
vive con más estrés oxidativo

En tres complicaciones,
el glutatión aparece más bajo

Más antioxidante
no siempre es mejor

Cuando baja el estrógeno,
sube el desgaste

Huesos, corazón y músculo
sienten el cambio

Con la edad baja el glutatión,
y vuelve si se le da la materia prima

Lo que se ha medido

1. Forman HJ et al. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med 2009;30:1-12.
2. Lu SC Glutathione synthesis. Biochim Biophys Acta 2013;1830:3143-53.
3. Wu G et al. Glutathione metabolism and its implications for health. J Nutr 2004;134:489-92.
4. Kent KD et al. Effect of whey protein isolate on intracellular glutathione and oxidant-induced cell death in human prostate epithelial cells. Toxicol In Vitro 2003;17:27-33.
5. Dröge W et al. Glutathione and immune function. Proc Nutr Soc 2000;59:595-600.
6. National Institute of Mental Health. The Teen Brain: 7 Things to Know. NIMH, 2023.
7. Gogtay N et al. Dynamic mapping of human cortical development during childhood through early adulthood. PNAS 2004;101:8174-9.
8. Cobley JN et al. 13 reasons why the brain is susceptible to oxidative stress. Redox Biol 2018;15:490-503.
9. Cabungcal JH et al. Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia. Neuron 2014;83:1073-1084.
10. Organización Mundial de la Salud. Salud mental del adolescente. Nota descriptiva, 2025.
11. Freed RD et al. A pilot study of cortical glutathione in youth with depression. Psychiatry Res Neuroimaging 2017;270:54-60.
12. Katrenčíková B et al. Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial. Antioxidants 2021;10.
13. Su L et al. Circulating biomarkers of oxidative stress in people with acne vulgaris: a systematic review and meta-analysis. Arch Dermatol Res 2024;316:105.
14. Ikeno H et al. Decrease in glutathione may be involved in pathogenesis of acne vulgaris. J Cosmet Dermatol 2011;10:240-4.
15. Varamenti E et al. Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis. Sports Med Open 2020;6:34.
16. Trivedi MS et al. Short-term sleep deprivation leads to decreased systemic redox metabolites and altered epigenetic status. PLoS One 2017;12:e0181978.
17. Rubinstein ML et al. Adolescent Exposure to Toxic Volatile Organic Chemicals From E-Cigarettes. Pediatrics 2018;141.
18. Burton GJ et al. Oxidative stress. Best Pract Res Clin Obstet Gynaecol 2011;25:287-99.
19. Al-Sheikh YA et al. Molecular and biochemical investigations of key antioxidant/oxidant molecules in Saudi patients with recurrent miscarriage. Exp Ther Med 2019;18:4450-4460.
20. Sturman JA et al. Absence of cystathionase in human fetal liver: is cystine essential? Science 1970;169:74-6.

21. Knapen MF et al. Low whole blood glutathione levels in pregnancies complicated by preeclampsia or the hemolysis, elevated liver enzymes, low platelets syndrome. Obstet Gynecol 1998;92:1012-5.
22. Aljaser FS et al. Glutathione and oxidized nicotinamide adenine dinucleotide (NAD(+)) redox status in plasma and placental tissue of Saudi patients with intrauterine growth restriction. Saudi Med J 2021;42:491-498.
23. Roberts JM et al. Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med 2010;362:1282-91.
24. Poston L et al. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet 2006;367:1145-54.
25. Organización Mundial de la Salud. Recomendaciones de la OMS sobre atención prenatal para una experiencia positiva del embarazo. 2016.
26. Sánchez-Rodríguez MA et al. Menopause as risk factor for oxidative stress. Menopause 2012;19:361-7.
27. Sánchez-Rodríguez MA et al. Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study. PLoS One 2019;14:e0214264.
28. Bellanti F et al. Sex hormones modulate circulating antioxidant enzymes: impact of estrogen therapy. Redox Biol 2013;1:340-6.
29. Zhao F et al. Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis. Arch Osteoporos 2021;16:4.
30. Lean JM et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 2003;112:915-23.
31. El Khoudary SR et al. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association. Circulation 2020;142:e506-e532.
32. Juppi HK et al. Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women. J Clin Med 2020;9.
33. Kuo YY et al. Effect of Whey Protein Supplementation in Postmenopausal Women: A Systematic Review and Meta-Analysis. Nutrients 2022;14.
34. Sekhar RV et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr 2011;94:847-53.
35. Kumar P et al. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci 2023;78:75-89.
36. Minich DM et al. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients 2019;11.
37. Chełchowska M et al. Influence of Oxidative Stress Generated by Smoking during Pregnancy on Glutathione Status in Mother-Newborn Pairs. Antioxidants 2021;10.
38. Lauterburg BH et al. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988;29:1153-7.
39. The North American Menopause Society The 2022 hormone therapy position statement of The North American Menopause Society. Menopause 2022;29:767-794.
40. Health Canada. Licensed Natural Health Products Database: Immunocal / HMS-90, NPN 80004370. Consultada en octubre de 2026.
41. Lands LC et al. Effect of supplementation with a cysteine donor on muscular performance. J Appl Physiol 1999;87:1381-5.
42. Grey V et al. Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein. J Cyst Fibros 2003;2:195-8.
43. Organización Mundial de la Salud. Cáncer de mama. Nota descriptiva, actualizada el 3 de julio de 2026.
44. US Preventive Services Task Force. Screening for Breast Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 2024;331:1918-1930.
45. Karelis AD et al. Effect of cysteine-rich whey protein (immunocal®) supplementation in combination with resistance training on muscle strength and lean body mass in non-frail elderly subjects: a randomized, double-blind controlled study. J Nutr Health Aging 2015;19:531-6.